XGMix is a State-of-the-Art method for Local Ancestry Inference based on XGBoost systems that comes with pre-trained sets for each chromosome. XGMix consists of two layers of stacked gradient boosted trees (a genomic window-specific layer and a window aggregating smoother) that can infer local ancestry with classification probabilities along each individual chromosome. A first level of parallel XGBoosts trees performs an initial estimation of the ancestry. A unique XGBoost then passes the initial estimates through a sliding window and outputs the final ancestry estimates.

The genetic variants used for XGMix are single nucleotide polymorphims (SNPs).

XGMix provides the end user with a detailed picture of their ancestry history as reflected by their individual chromosomes. Our genetic makeup is the result of our ancestors' journeys, tribulations and love stories through time and some of these aspects might surface in you, your close relatives or later on in your descendants. Get ready to travel back in time and let us know how this information resonates with you.

Ancestry inference is a common problem addressed by AI methods and a known limitation for their successful application to Real World Data (RWD) is their poor performance on admixed individuals. This lack of performance is mainly due to the lack of properly labeled reference populations required to train models and better deployment of existing algorithms. XGMix has propietary reference populations and algorithm design that together surpass ancestry accuracy prediction by other providers.

XGMix assigns ancestry with a higher resolution than approaches from other providers. Our patented algorithm can be tailored to be as precise as needed for either commercial or clinical purposes.

We are multitudes. Although each one of our chromosomes are currently travelling together they have their own evolutionary history separated from each other. Each one of our ancestors received a copy for each chromosome from their parents and just before passing them down to their descendants they were reshulffled at the individual chromosome level. Every reshuffling is random and over generations this is reflected in the diversity of origin exhibited by each individual chromosome.