Is your dog allergy in your DNA? Uncover your story through the power of genomic science.
Dogs are the most adorable, loving, wonderful, loyal, joyous creatures in the world. But if you have a dog allergy, your relationship with cute little canines might be complicated.
It’s not even a matter of simply not owning a dog, either. Dogs are ubiquitous; roughly 57% of U.S. households have at least one dog. If you have a dog allergy, it’s not necessarily something you have to address only when you are next to a dog; pet dander can travel fairly efficiently. What’s more, it sticks to clothing and upholstery and can be transferred easily and unknowingly. So, if you work with someone who has a dog, you might experience an allergic response even if the dog isn’t in the room.
It is estimated that roughly 30% of people have an active dog allergy at any given time, and at least 75% of people develop an allergic reaction once in their lifetime. The prevalence of allergies in the industrialized world is increasing, particularly in urban areas.
Are allergies genetic or environmental? While the environment might contribute to allergic responses, we are increasingly learning that allergies might be encoded in our genetic makeup.
When a person has a dog allergy, it is usually not the actual animal they are allergic to, but the dander produced by the dog’s skin. Often, these allergic reactions produce excessive sneezing and a runny nose.
Allergic responses are the immune system’s overcompensation when certain particles enter the body. The allergen interacts with inflammatory cells, which infiltrate the nasal lining, where inflammatory cells cause immunoglobulin E (IgE) production by plasma cells. This immunoglobulin production, in turn, triggers mast cells to release mediator molecules such as histamine, leukotrienes, and cytokines. The release of these mediators causes the onset of an allergic reaction. Pollen, pets, molds, and mites are the most common allergens.
The inherited component of an allergic response is supported by three recent genome-wide association studies (GWAS) on Europeans and North Americans, which identified 47 related single nucleotide polymorphisms (SNPs) altogether.
In one of the studies, skin prick tests were performed using common inhalant allergens on 432 study participants. For the first time, a specific SNP, rs7775228 located on the human leukocyte antigen gene (HLA-DQB1), was found to be associated with dog dander-specific allergic sensitivity. Participants with at least one copy of the C allele were more likely to exhibit a dog allergy. HLA-DQB1 is a protein-coding gene and plays a critical role in the immune system.
Knowing your genetic predisposition to allergies will help you make the best choices about your health and lifestyle. An in-depth DNA analysis of your raw DNA file will empower you with the information you need to live your best life.
You can download your raw DNA file if you performed an at-home DNA test from AncestryDNA, 23andMe, or another provider. Genomelink can perform a comprehensive evaluation of your genetic makeup, helping you better understand your genetic characteristics.
Are you interested in learning more about your genetic tendency for dog allergies? Let the team at Genomelink help you unlock your full potential.
Uncover your genetic potential by signing up with Genomelink today!
Photo by Joe Caione on Unsplash
